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Article

Proficiency test of BRAF immunohistochemistry as a surrogate marker of p.V600E mutation: Assessment of staining and interpretation quality in Taiwan.

Virchows Archiv : an international journal of pathology - 1 May 2026

Chen Yun-An, Lai Jyie-Yu, Hsu Chih-Yi, Lien Huang-Chun, Hang Jen-Fan

Abstract excerpt

BRAF immunohistochemistry (IHC) serves as a surrogate for BRAF p.V600E but shows variable performance across tumor types and institutions. This study evaluated BRAF IHC staining quality and interpretation in general pathology laboratories through a nationwide proficiency test (PT) in Taiwan, focusing on the most commonly encountered thyroid neoplasm and colorectal cancer. This PT was organized by the Taiwan...

Topics

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Biomarkers, Tumor
Colorectal Neoplasms
Immunohistochemistry
Proto-Oncogene Proteins B-raf
Reproducibility of Results

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Thyroid Neoplasms

Tissue Array Analysis

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Open in PubMed Open full text

Identifiers

PMID: 40689945
DOI: 10.1007/s00428-025-04192-5
PMCID: PMC13176039

Genes

BRAF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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