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Article

Pregnancy precipitates metabolic imbalance and accelerates death in an animal model of mitochondrial cardiomyopathy.

Molecular metabolism - 1 May 2026

Sayles Nicole M, Casalena Gabriella, Zhao Dazhi, Dellinger Ryan W, Holmes Holly E, Manzo Onorina, Galkin Alexander, Di Lorenzo Annarita, Manfredi Giovanni

Abstract excerpt

During pregnancy, the heart undergoes major physiological and metabolic changes to increase cardiac workload, and the demand for energy production is especially elevated during the trial of labor. Normally, cardiac structure and metabolism revert to the pre-pregnancy state shortly after delivery. However, in some cases, peripartum/postpartum cardiomyopathy (PPCM) occurs, which increases a person's risk of major...

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Source

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Identifiers

PMID: 41850395
DOI: 10.1016/j.molmet.2026.102352
PMCID: PMC13090321

Genes

CHCHD10

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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