Article

High fat diet ameliorates mitochondrial cardiomyopathy in CHCHD10 mutant mice

2023-02-22

Abstract excerpt

Mutations in CHCHD10 , a mitochondrial protein with undefined functions, are associated with autosomal dominant mitochondrial diseases. Chchd10 knock-in mice harboring a heterozygous S55L mutation (equivalent to human pathogenic S59L) develop a fatal mitochondrial cardiomyopathy caused by CHCHD10 aggregation and proteotoxic mitochondrial integrated stress response (mtISR). In mutant hearts, mtISR is accompanied...

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Literature Corpus work: 53b4b3a6-d485-56fd-bf38-760ecb1cadb4
DOI: 10.1101/2023.02.22.529577

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