Genetic overlap of chronic pain, musculoskeletal-specific pain, substance use disorders and substance use consumption: Common addiction and substance-specific effects.

doi:10.1111/add.70387

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Article

Genetic overlap of chronic pain, musculoskeletal-specific pain, substance use disorders and substance use consumption: Common addiction and substance-specific effects.

Addiction (Abingdon, England) - 1 Jul 2026

Rader Lydia, Zorina-Lichtenwalter Katerina, Hatoum Alexander S, Stallings Michael C, Wager Tor D, Friedman Naomi P

Abstract excerpt

BACKGROUND AND AIMS: Chronic pain and substance use disorders frequently co-occur and may share general addiction-related and substance-specific genetic pathways. Additionally, substance consumption and problematic use may differ in their genetic associations with pain subtypes. We applied genomic structural equation modeling to assess shared genetic and neurological enrichment between general and...

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