Article
Genetic mapping of habitual substance use, obesity-related traits, responses to mental and physical stress, and heart rate and blood pressure measurements reveals shared genes that are overrepresented in the neural synapse.
Hypertension research : official journal of the Japanese Society of Hypertension - 1 Jun 2012
Nikpay Majid, Šeda Ondrej, Tremblay Johanne, Petrovich Milan, Gaudet Daniel, Kotchen Theodore A, Cowley Allen W, Hamet Pavel
Abstract excerpt
Links between substance use habits, obesity, stress and the related cardiovascular outcomes can be, in part, because of loci with pleiotropic effects. To investigate this hypothesis, we performed genome-wide mapping in 119 multigenerational families from a population in the Saguenay-Lac-St-Jean region with a known founder effect using 58,000 single-nucleotide polymorphisms and 437 microsatellite markers to...
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