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Article

Impact of CYP2D6 Genotype and Inhibitor Use on Risperidone Metabolism in Children: Functional Insights Into the 17 and 29 Alleles.

Clinical and translational science - 1 Mar 2026

Bennett Matthew H, Poweleit Ethan A, Vaughn Samuel E, Retke Brandon, Toren Paul, Strawn Jeffrey R, Ramsey Laura B

Abstract excerpt

Risperidone, an atypical antipsychotic, is increasingly prescribed in pediatric patients with psychiatric disorders. It is primarily metabolized by CYP2D6 to 9-hydroxyrisperidone, an active metabolite associated with a higher risk of adverse effects. The CYP2D6*17 and *29 alleles are prevalent in individuals of African ancestry and less studied than variants found in European ancestry individuals. This knowledge...

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Identifiers

PMID: 41845570
DOI: 10.1111/cts.70525
PMCID: PMC13093649

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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