Article
CYP2D6 genotype and adverse events to risperidone in children and adolescents.
Pediatric research - 1 Apr 2019
Oshikoya Kazeem A, Neely Katelyn M, Carroll Robert J, Aka Ida T, Maxwell-Horn Angela C, Roden Dan M, Van Driest Sara L
Abstract excerpt
BACKGROUND: There are few and conflicting data on the role of cytochrome P450 2D6 (CYP2D6) polymorphisms in relation to risperidone adverse events (AEs) in children. This study assessed the association between CYP2D6 metabolizer status and risk for risperidone AEs in children. METHODS: Children ≤18 years with at least 4 weeks of risperidone exposure were identified using BioVU, a de-identified DNA biobank linked...
Read the complete abstract on PubMedTopics
- Adolescent
- Alleles
- Child
- Cytochrome P-450 CYP2D6
- Electronic Health Records
- Female
- Genotype