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Article

Impact of CYP2D6 Polymorphism on Steady-State Plasma Levels of Risperidone and 9-Hydroxyrisperidone in Thai Children and Adolescents with Autism Spectrum Disorder.

Journal of child and adolescent psychopharmacology - 1 Mar 2017

Vanwong Natchaya, Ngamsamut Nattawat, Medhasi Sadeep, Puangpetch Apichaya, Chamnanphon Montri, Tan-Kam Teerarat, Hongkaew Yaowaluck, Limsila Penkhae, Sukasem Chonlaphat

Abstract excerpt

OBJECTIVE: The purpose of this study was to investigate the influence of CYP2D6 gene polymorphisms on plasma concentrations of risperidone and its metabolite in Thai children and adolescents with autism spectrum disorder (ASD). METHODS: All 97 autism spectrum disorder patients included in this study had been receiving risperidone at least for 1 month. The CYP2D6 genotypes were determined by real-time polymerase...

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Identifiers

PMID: 26780783
DOI: 10.1089/cap.2014.0171

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