Article
The Frequency of CYP2D6 and CYP3A4/5 Genotypes and The Impact of Their Allele Translation and Phenoconversion-Predicted Enzyme Activity on Risperidone Pharmacokinetics in Saudi Children with Autism.
Biochemical genetics - 1 Aug 2024
Shilbayeh Sireen Abdul Rahim, Adeen Iman Sharaf, Alhazmi Ayman Shawqi, Ibrahim Samah Fathy, Al Enazi Fawwaz Abdul Razaq, Ghanem Ezzeldeen Hasan, Binduraihem Adel Mohammed
Abstract excerpt
Data on the role of CYP2D6 and CYP3A4/5 polymorphisms in relation to risperidone (RIS) pharmacokinetics (PK) in children are relatively limited and inconsistent. This is partially attributable to the limited coverage of CYP2D6 and CYP3A4/5 metabolizer phenotypes, particularly those of poor and ultrarapid metabolizers (PMs and UMs), which has led to calls for studies of populations with a non-European background...
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