Article
Inhibition of AKT1 signaling promotes invasion and metastasis of non-small cell lung cancer cells with K-RAS or EGFR mutations.
Scientific reports - 1 Aug 2017
Rao Guanhua, Pierobon Mariaelena, Kim In-Kyu, Hsu Wei-Hsun, Deng Jianghong, Moon Yong-Wha, Petricoin Emanuel F, Zhang Yu-Wen, Wang Yisong, Giaccone Giuseppe
Abstract excerpt
Accumulating evidence supports a role of the PI3K-AKT pathway in the regulation of cell motility, invasion and metastasis. AKT activation is known to promote metastasis, however under certain circumstances, it also shows an inhibitory activity on metastatic processes, and the cause of such conflicting results is largely unclear. Here we found that AKT1 is an important regulator of metastasis and down-regulation...
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