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Article

Differential enhancement of breast cancer cell motility and metastasis by helical and kinase domain mutations of class IA phosphoinositide 3-kinase.

Cancer research - 1 Dec 2009

Pang Huan, Flinn Rory, Patsialou Antonia, Wyckoff Jeffrey, Roussos Evanthia T, Wu Haiyan, Pozzuto Maria, Goswami Sumanta, Condeelis John S, Bresnick Anne R, Segall Jeffrey E, Backer Jonathan M

Abstract excerpt

Class IA (p85/p110) phosphoinositide 3-kinases play a major role in regulating cell growth, survival, and motility. Activating mutations in the p110alpha isoform of the class IA catalytic subunit (PIK3CA) are commonly found in human cancers. These mutations lead to increased proliferation and tra...

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Identifiers

PMID: 19903845
DOI: 10.1158/0008-5472.CAN-09-1968
PMCID: PMC2793177

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-19903845-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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