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Article

Polygenic scores for executive functioning as predictors of performance improvements after repeated testing in major psychiatric disorders.

Scientific reports - 16 Mar 2026

Navarro-Flores Alba, Heilbronner Maria, Rafiee Hajar, Wendel Bernadette, Papiol Sergi, Adorjan Kristina, Budde Monika, Oraki Kohshour Mojtaba, Schulte Eva C, Reich-Erkelenz Daniela, Senner Fanny, Anghelescu Ion-George, Arolt Volker, Baune Bernhard T, Dannlowski Udo, Dietrich Detlef E, Fallgatter Andreas J, Figge Christian, Lang Fabian U, Juckel Georg, Konrad Carsten, Reimer Jens, Reininghaus Eva Z, Schmauß Max, Schmitt Andrea, Spitzer Carsten, Wiltfang Jens, Zimmermann Jörg, Falkai Peter, Schulze Thomas G, Heilbronner Urs

Abstract excerpt

Executive Functions (EF) control goal-oriented behaviors and are disrupted in patients with psychiatric disorders (PPD). Repeated EF testing in clinical practice and research aims to evaluate disease progression and treatment efficacy. Performance improvements (or “practice effects”) are expected, while deficiencies had been proposed as markers of conversion to dementia. Given the high conversion risk in PPD,...

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Identifiers

PMID: 41840026
DOI: 10.1038/s41598-026-41345-1
PMCID: PMC12996620

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