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Article

Polygenic risk for schizophrenia predicting test-measured and self-reported cognitive performance in individuals without psychosis.

BMC psychiatry - 12 Jan 2026

Rosenqvist Elena, Lyytikäinen Leo-Pekka, Sormunen Elina, Kähönen Mika, Raitakari Olli, Hietala Jarmo, Pahkala Katja, Lehtimäki Terho, Keltikangas-Järvinen Liisa, Rovio Suvi, Saarinen Aino

Abstract excerpt

INTRODUCTION: Schizophrenia is characterized by weaker test-measured cognitive performance, which is partially explained by disease-related secondary factors (after the onset of the disorder) such as side effects of antipsychotics, stigma, or sedentary behavior. We examined whether polygenic risk for schizophrenia (PRSSCZ) is associated with (a) test-measured or (b) self-reported cognitive performance in...

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Identifiers

PMID: 41526855
DOI: 10.1186/s12888-026-07775-x
PMCID: PMC12797622

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