Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ceftazidime-avibactam-resistant Klebsiella pneumoniae driven by multiple β-lactamase mutations: a hospital outbreak report.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases - 1 Sept 2026

Yang Weiwei, Tang Chengkang, Shi Qingyu, Ou Hongjian, Yin Dandan, Han Renru, Chen Jinhong, Guo Yan, Hu Fupin

Abstract excerpt

OBJECTIVES: This study aimed to trace the clonal dissemination of ceftazidime-avibactam-resistant Klebsiella pneumoniae and clarify the complex ceftazidime-avibactam resistance mechanism caused by multiple β-lactamase variants. METHODS: Six ceftazidime-avibactam-resistant K. pneumoniae clinical strains were isolated from six inpatients in the hepatobiliary surgery department. The antimicrobial resistance...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Azabicyclo Compounds
Share to beta-Lactamases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ceftazidime

Share to Cross Infection

Share to Drug Combinations

Share to Drug Resistance, Multiple, Bacterial

Share to Klebsiella Infections

Share to Klebsiella pneumoniae

Source

Identifiers

PMID: 41839419
DOI: 10.1016/j.cmi.2026.03.014

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ceftazidime-avibactam-resistant Klebsiella pneumoniae driven by multiple β-lactamase mutations: a hospital outbreak report.PMID 41839419Read ↗

A large-scale surveillance revealed that KPC variants mediated ceftazidime-avibactam resistance in clinically isolated Klebsiella pneumoniae.Semantic proximity Read ↗

Suboptimal ceftazidime-avibactam exposure drives sequential blaKPC mutations and intra-host coexistence of Klebsiella pneumoniae harboring distinct variants leading to persistent infection.Semantic proximity Read ↗

Evolution of ceftazidime-avibactam resistance driven by mutations in double-copy blaKPC-2 to blaKPC-189 during treatment of ST11 carbapenem-resistant Klebsiella pneumoniae.Semantic proximity Read ↗

Emergence of Ceftazidime-Avibactam Resistance Due to Plasmid-Borne blaKPC-3 Mutations during Treatment of Carbapenem-Resistant Klebsiella pneumoniae Infections.Semantic proximity Read ↗

Emergence of ceftazidime-avibactam resistance due to a novel blaKPC-2 mutation during treatment of carbapenem-resistant Klebsiella pneumoniae infections.Semantic proximity Read ↗

In vivo evolution of resistant subpopulations of KPC-producing Klebsiella pneumoniae during ceftazidime/avibactam treatment.Semantic proximity Read ↗

Stepwise KPC mutational accumulation confers high-level ceftazidime-avibactam resistance in ST11 carbapenem-resistant Klebsiella pneumoniae.Semantic proximity Read ↗

In vivo evolution to hypermucoviscosity and ceftazidime/avibactam resistance in a liver abscess caused by Klebsiella pneumoniae sequence type 512.Semantic proximity Read ↗

Dynamic evolution of ceftazidime–avibactam resistance due to interchanges between blaKPC-2 and blaKPC-145 during treatment of Klebsiella pneumoniae infectionSemantic proximity Read ↗

Molecular mechanisms responsible KPC-135-mediated resistance to ceftazidime-avibactam in ST11-K47 hypervirulent Klebsiella pneumoniaeSemantic proximity Read ↗

Activity of Ceftazidime-Avibactam Against Clinical Isolates of Klebsiella pneumoniae, Including KPC-Carrying Isolates, Endemic to New York City.Semantic proximity Read ↗

Reduced Ceftazidime-Avibactam Susceptibility in KPC-Producing Klebsiella pneumoniae From Patients Without Ceftazidime-Avibactam Use History – A Multicenter Study in ChinaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.