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Article

In vivo evolution of resistant subpopulations of KPC-producing Klebsiella pneumoniae during ceftazidime/avibactam treatment.

The Journal of antimicrobial chemotherapy - 1 Jun 2018

Gaibani Paolo, Campoli Caterina, Lewis Russell E, Volpe Silvia Lidia, Scaltriti Erika, Giannella Maddalena, Pongolini Stefano, Berlingeri Andrea, Cristini Francesco, Bartoletti Michele, Tedeschi Sara, Ambretti Simone

Abstract excerpt

Objectives: KPC-producing Klebsiella pneumoniae (KPC-Kp) represent a serious problem worldwide. Herein, we describe the evolution of ceftazidime/avibactam resistance by sequencing longitudinal clinical isolates from a patient with KPC-Kp bloodstream infection undergoing ceftazidime/avibactam treatment. Methods: WGS was performed on one ceftazidime/avibactam-susceptible KPC-Kp (BOT-CA-S) and two phenotypically...

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PMID: 29566151
DOI: 10.1093/jac/dky082

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