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Emergence of Ceftazidime-Avibactam Resistance Due to Plasmid-Borne blaKPC-3 Mutations during Treatment of Carbapenem-Resistant Klebsiella pneumoniae Infections.

Antimicrobial agents and chemotherapy - 1 Mar 2017

Shields Ryan K, Chen Liang, Cheng Shaoji, Chavda Kalyan D, Press Ellen G, Snyder Avin, Pandey Ruchi, Doi Yohei, Kreiswirth Barry N, Nguyen M Hong, Clancy Cornelius J

Abstract excerpt

Ceftazidime-avibactam is a novel β-lactam/β-lactamase inhibitor with activity against carbapenem-resistant Enterobacteriaceae (CRE) that produce Klebsiella pneumoniae carbapenemase (KPC). We report the first cases of ceftazidime-avibactam resistance to develop during treatment of CRE infections and identify resistance mechanisms. Ceftazidime-avibactam-resistant K. pneumoniae emerged in three patients after...

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PMID: 28031201
DOI: 10.1128/AAC.02097-16
PMCID: PMC5328542

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