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PaREx: an open-source pipeline for the automated analysis of Pseudomonas aeruginosa resistomes from whole-genome sequences.

Antimicrobial agents and chemotherapy - 1 Apr 2026

López-Causapé Carla, Bonet Matias, Taltavull Biel, Medina-Retiga Paola, Sastre-Femenía Miquel A, Cortés-Lara Sara, Gomis-Font María A, Gomez-Romano Fernando, Oliver Antonio

Abstract excerpt

Whole-genome sequencing (WGS) has become a valuable tool for bacterial typing and resistome analysis. However, most existing antibiotic resistance databases and bioinformatics tools are not useful for P. aeruginosa resistome profiling as they fail to detect mutation-driven antibiotic resistance mechanisms. In addition, the increasing diversity of AmpC variants (Pseudomonas-derived cephalosporinases [PDCs]) in...

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PMID: 41837617
DOI: 10.1128/aac.01326-25
PMCID: PMC13041343

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