Phylogenomic and phenotypic profiling of carbapenem-resistant Pseudomonas aeruginosa clinical isolates reveals lineage-specific resistance mechanisms and adaptive responses.

doi:10.1099/mgen.0.001639

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Phylogenomic and phenotypic profiling of carbapenem-resistant Pseudomonas aeruginosa clinical isolates reveals lineage-specific resistance mechanisms and adaptive responses.

Microbial genomics - 1 Feb 2026

Torres-Rodríguez Humberto, Garza-González Elvira, Colín-Castro Claudia Adriana, Martínez-Zavaleta María Guadalupe, Rojas-Larios Fabian, Vázquez-Larios María Del Rosario, Mireles-Dávalos Christian Daniel, Romero-Romero Daniel, Sandoval-Villaseñor Pablo Hernan, Martínez-Guerra Bernardo Alfonso, Flores-Huacuja Marlen, Córdova-Fletes Carlos, García-Morales Griselda, Castañeda-Duarte Juan de Dios, Silva-Gamiño Aldo Rafael, Adame-Álvarez César, Ávila-Cárdenas Brenda Berenice, Morales-De-La-Peña Cecilia Teresita, Hernández-Vicente Lourdes, Flores-Castillo Frynne Magaly, De-la-Cruz-Hernández Ibis, Choy-Chang Elena Victoria, Mena-Ramírez Juan Pablo, López-Gutiérrez Eduardo, Gil-Veloz Mariana, Pérez-Vicelis Talia, López-Moreno Laura Isabel, Barajas-Magallón Juan Manuel, González-Melgoza Paulina Fabiola, Moreno-Méndez Martha Irene, Galindo-Méndez Mario, Ramírez-Alanís Eloísa, Garza-Ramos Ulises, López-Jácome Luis Esau

Abstract excerpt

Carbapenem resistance in Pseudomonas aeruginosa is a growing public health concern. Multiple mechanisms of antimicrobial resistance have been described. While surveillance often focuses on carbapenemase detection, non-carbapenemase mechanisms and their interplay with the genomic background remain underexplored. This study aimed to characterize how genomic background influences carbapenem resistance mechanisms and...

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Pseudomonas aeruginosa
Phylogeny
Carbapenems
Anti-Bacterial Agents

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

beta-Lactamases

Pseudomonas Infections

Microbial Sensitivity Tests

Bacterial Proteins

Phenotype

Mexico

Porins

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PMID: 41661184
DOI: 10.1099/mgen.0.001639
PMCID: PMC12888230

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