Article
Coexistence and within-host evolution of diversified lineages of hypermutable Pseudomonas aeruginosa in long-term cystic fibrosis infections.
PLoS genetics - 1 Oct 2014
Feliziani Sofía, Marvig Rasmus L, Luján Adela M, Moyano Alejandro J, Di Rienzo Julio A, Krogh Johansen Helle, Molin Søren, Smania Andrea M
Abstract excerpt
The advent of high-throughput sequencing techniques has made it possible to follow the genomic evolution of pathogenic bacteria by comparing longitudinally collected bacteria sampled from human hosts. Such studies in the context of chronic airway infections by Pseudomonas aeruginosa in cystic fibrosis (CF) patients have indicated high bacterial population diversity. Such diversity may be driven by hypermutability...
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