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Article

Acquisition of antimicrobial-resistant variants in repeated infections caused by Pseudomonas aeruginosa revealed by whole genome sequencing.

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy - 1 Feb 2019

Nakanishi Noriko, Nomoto Ryohei, Sato Kanako, Koike Chihiro, Kusuki Mari, Nakamura Tatsuya, Shigemura Katsumi, Shirakawa Toshiro, Fujisawa Masato, Tokimatsu Issei, Osawa Kayo

Abstract excerpt

Pseudomonas aeruginosa, responsible for serious nosocomial-acquired infections, possesses intrinsic antibiotic resistance mechanisms and commonly exhibits multidrug resistance. Here, we report the evolving resistance profiles of strains isolated from the sputum of a patient being treated for repeated P. aeruginosa infections following cancer resection. Whole genome sequencing of six isolates obtained over a...

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PMID: 30126693
DOI: 10.1016/j.jiac.2018.07.016

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