Article
Environmental heterogeneity drives within-host diversification and evolution of Pseudomonas aeruginosa.
mBio - 16 Sept 2014
Markussen Trine, Marvig Rasmus Lykke, Gómez-Lozano María, Aanæs Kasper, Burleigh Alexandra E, Høiby Niels, Johansen Helle Krogh, Molin Søren, Jelsbak Lars
Abstract excerpt
UNLABELLED: Microbial population polymorphisms are commonly observed in natural environments, including long-term infected hosts. However, the underlying processes promoting and stabilizing diversity are difficult to unravel and are not well understood. Here, we use chronic infection of cystic fibrosis airways by the opportunistic pathogen Pseudomonas aeruginosa as a system for investigating bacterial...
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