Article
Phenotypic profiling of pristane-induced mimicking human systemic lupus erythematosus in Macaca fascicularis.
Animal models and experimental medicine - 1 Jul 2026
Jonny Jonny, Wirjopranoto Soetojo, Nidom Chairul A, Sudiana I Ketut, Putranto Terawan A, Pratiwi Elisa D, Mawaddah Tiza W, Nidom Astria N, Nidom Reviany V, Indrasari Setyarina, Rosytania Irma Y, Yana Hiqmah Y, Kusumastuti Sanindita
Abstract excerpt
BACKGROUND: The development of nonhuman primate models that replicate human systemic lupus erythematosus (SLE) remains limited. This study aimed to develop a pristane-induced SLE model in Macaca fascicularis and evaluate its capacity to mimic human-like clinical and laboratory immunological alterations. METHODS: An experimental, single-arm investigation was performed using six female M. fascicularis (2-3 years...
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