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Article

Impact of non-synonymous mutations on the structure and function of telomeric repeat binding factor 1.

Journal of biomolecular structure & dynamics - 1 Jan 2022

Habib Insan, Khan Shama, Mohammad Taj, Hussain Afzal, Alajmi Mohamed F, Rehman Tabish, Anjum Farah, Hassan Md Imtaiyaz

Abstract excerpt

Telomeric repeat binding factor 1 (TRF1) is one of the major components of the shelterin complex. It directly binds to the telomere and controls its function by regulating the telomerase acting on it. Several variations are reported in the TRF1 gene; some are associated with variety of diseases. Here, we have studied the structural and functional significance of these variations in the TRFH domain of TRF1. We...

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PMID: 33982644
DOI: 10.1080/07391102.2021.1922313

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