Article
Integrated Liquid Biopsy and Tumor Tissue Genomic Profiling of Appendiceal Cancer: cfDNA Burden, Mutation Landscapes, and Clinical Outcomes.
Annals of surgical oncology - 1 Jul 2026
Patel Sefali, Petrosko Patricia, Gallo Phillip H, Myers Madeline, Gil Louis, Nolan Edward J, Hosseiny Seyed H, Blodgett Rose, Omstead Ashten, Park Hyun, Dalton Emily, Sherry Christopher, Goel Ajay, Allen Casey J, Zaidi Ali, Schwartz Russell, Bartlett David L, Wagner Patrick L, LaFramboise William A
Abstract excerpt
BACKGROUND: Appendiceal cancer (AC) is a rare malignancy that often presents at advanced stages with significant histological variability influencing clinical outcomes. Precise genomic profiling is essential for accurate diagnosis and personalized patient management. This study interrogated DNA from appendiceal tumor tissue, buffy coat cells, and the cell-free DNA component of plasma using a 523-gene panel for...
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