Article

Cell-Free DNA Concentration as a Mutation-Agnostic Readout of Systemic Tumor Burden and Prognosis: A Prospective Analysis of 1,000 Patients

2026-07-28

Abstract excerpt

<h4>Background</h4> <h4>Objective: </h4> assessment of tumor burden in patients with solid tumors remains inexact. Furthermore, while mutation-based liquid biopsies are specific, they are limited by tumor heterogeneity and the requirement for detectable clonal mutations. Cell-free DNA (cfDNA) concentration, a cost-effective substrate for mutation-focused liquid biopsy, has shown promise as a “molecular tumor burd...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 66e19fc7-97f6-5cd1-a938-5975e68aea3e
DOI: 10.64898/2026.07.27.26359064

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Cell-Free DNA Concentration as a Mutation-Agnostic Readout of Systemic Tumor Burden and Prognosis: A Prospective Analysis of 1,000 PatientsDOI 10.64898/2026.07.27.26359064Read

Cell-Free DNA, Tumor Molecular Concordance, and Clinical Correlates of Patients with Cancer Treated in a Large Community Health Care NetworkSemantic proximity Read

Assessing the Concordance of Genomic Alterations between Circulating-Free DNA and Tumour Tissue in Cancer PatientsSemantic proximity Read

Liquid biopsies across the cancer care continuum.Semantic proximity Read

Circulating Cell-Free DNA-Based Comprehensive Molecular Analysis of Biliary Tract Cancers Using Next-Generation SequencingSemantic proximity Read

Cell‐free DNA‐associated multi‐feature applications in cancer diagnosis and treatmentSemantic proximity Read

Diagnostic and Therapeutic Potential of Circulating-Free DNA and Cell-Free RNA in Cancer ManagementSemantic proximity Read

Clinical applications of cell-free DNA-based liquid biopsy analysisSemantic proximity Read

Cell-free DNA (cfDNA): Clinical Significance and Utility in Cancer Shaped By Emerging TechnologiesSemantic proximity Read

Genome-wide cell-free DNA mutational integration enables ultra-sensitive cancer monitoring.Semantic proximity Read

Exploring the Role of Circulating Cell-Free DNA in Disease Diagnosis and TherapySemantic proximity Read

Diagnostic and prognostic value of circulating tumor-related DNA in cancer patients.Semantic proximity Read

Validation and clinical evaluation of a comprehensive circulating tumor DNA assay for genomic profiling in solid tumorsSemantic proximity Read