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Humans with function-disrupting variants in the myostatin gene (MSTN) have increased skeletal muscle mass and strength, and less adiposity.

Nature communications - 13 Mar 2026

Herman Joseph L, Dornbos Peter, Landheer Karl, Geraghty Benjamin J, Egerman Marc A, Phan Duc, Germino Mary, Mastaitis Jason W, Walls Johnathon R, Lotta Luca A, Abecasis Gonçalo, Baras Aris, Altarejos Judith Y, Sleeman Mark W, Melander Olle, Shavlakadze Tea, Yancopoulos George D, Bovijn Jonas, Marchini Jonathan, Glass David J

Abstract excerpt

Myostatin negatively regulates skeletal muscle size in multiple species, and therefore, myostatin blockade has been therapeutically explored to promote muscle growth in humans, including to counter the muscle loss seen in obese humans using GLP1R agonists. In this study, we present results from a large multi-cohort genetic association analysis, using data from 1.1 million individuals to examine the effects of...

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Adiposity
Body Composition
Magnetic Resonance Imaging
Muscle, Skeletal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Muscle Strength

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Identifiers

PMID: 41826329
DOI: 10.1038/s41467-026-70422-2
PMCID: PMC13125550

Genes

MSTN
GLP1R

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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