Article

Genetically predicted levels of lithocholate sulfate mediate the association between the inflammatory factor MMP-1 and ischemic stroke

2024-12-09

Abstract excerpt

<title>Abstract</title> <p> Background This study aimed to investigate the causal relationship between the levels of the inflammatory factor matrix metalloproteinase-1 (MMP-1) and ischemic stroke (IS) and further examine the role of the metabolite lithocholate sulfate (LSL) as an intermediary factor. Methods We conducted a two-sample Mendelian randomization (MR) analysis on genetically predicted MMP-1 (14,744...

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Literature Corpus work: 40d8acc7-193b-5524-9a53-5e9a17cccfea
DOI: 10.21203/rs.3.rs-5290061/v1

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