Article
Isolation of reovirus T3D mutants capable of infecting human tumor cells independent of junction adhesion molecule-A.
PloS one - 1 Jan 2012
van den Wollenberg Diana J M, Dautzenberg Iris J C, van den Hengel Sanne K, Cramer Steve J, de Groot Raoul J, Hoeben Rob C
Abstract excerpt
Mammalian Reovirus is a double-stranded RNA virus with a distinctive preference to replicate in and lyse transformed cells. On that account, Reovirus type 3 Dearing (T3D) is clinically evaluated as oncolytic agent. The therapeutic efficacy of this approach depends in part on the accessibility of the reovirus receptor Junction Adhesion Molecule-A (JAM-A) on the target cells. Here, we describe the isolation and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.