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Article

The GM2 glycan serves as a functional coreceptor for serotype 1 reovirus.

PLoS pathogens - 1 Jan 2012

Reiss Kerstin, Stencel Jennifer E, Liu Yan, Blaum Bärbel S, Reiter Dirk M, Feizi Ten, Dermody Terence S, Stehle Thilo

Abstract excerpt

Viral attachment to target cells is the first step in infection and also serves as a determinant of tropism. Like many viruses, mammalian reoviruses bind with low affinity to cell-surface carbohydrate receptors to initiate the infectious process. Reoviruses disseminate with serotype-specific tropism in the host, which may be explained by differential glycan utilization. Although α2,3-linked sialylated...

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Identifiers

PMID: 23236285
DOI: 10.1371/journal.ppat.1003078
PMCID: PMC3516570

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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