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Article

Variant adiponutrin confers genetic protection against cholestatic itch.

Scientific reports - 9 Oct 2014

Krawczyk Marcin, Milkiewicz Malgorzata, Marschall Hanns-Ulrich, Bartz Clemens, Grünhage Frank, Wunsch Ewa, Milkiewicz Piotr, Lammert Frank

Abstract excerpt

Lysophosphatidic acid (LPA) mediates cholestatic pruritus. Recently the enzyme PNPLA3, expressed in liver and skin, was demonstrated to metabolise LPA. Here we assess the association of the PNPLA3 variant p.Ile148Met, known to be associated with (non-)alcoholic fatty liver disease (NAFLD) in geno...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25297933
DOI: 10.1038/srep06374
PMCID: PMC4190538

Genes

PNPLA3
LPA

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25297933-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Variant adiponutrin confers genetic protection against cholestatic itch.PMID 25297933Read ↗

PNPLA3 I148M variant and hepatocellular carcinoma: a common genetic variant for a rare disease.Semantic proximity Read ↗

Unravelling the pathogenesis of fatty liver disease: patatin-like phospholipase domain-containing 3 protein.Semantic proximity Read ↗

PNPLA3 p.I148M and TM6SF2 p.E167K variants do not predispose to liver injury in cholestatic liver diseases: A prospective analysis of 178 patients with PSC.Semantic proximity Read ↗

Patatin-like phospholipase domain-containing 3 I148M polymorphism, steatosis, and liver damage in chronic hepatitis C.Semantic proximity Read ↗

Homozygosity for the patatin-like phospholipase-3/adiponutrin I148M polymorphism influences liver fibrosis in patients with nonalcoholic fatty liver disease.Semantic proximity Read ↗

The PNPLA3 I148M variant modulates the fibrogenic phenotype of human hepatic stellate cells.Semantic proximity Read ↗

PNPLA3 I148M polymorphism and progressive liver disease.Semantic proximity Read ↗

Adiponutrin (PNPLA3) in liver fibrogenesis: Is unaltered HepG2 cell line a better model system compared to murine models?Semantic proximity Read ↗

Patatin-Like Phospholipase Domain-Containing 3 I148M Variant Is Associated with Liver Steatosis and Fat Distribution in Chronic Hepatitis B.Semantic proximity Read ↗

Identification of combined genetic determinants of liver stiffness within the SREBP1c-PNPLA3 pathway.Semantic proximity Read ↗

Impact of IL28B, ITPA and PNPLA3 genetic variants on therapeutic outcome and progression of hepatitis C virus infection.Semantic proximity Read ↗

Cryptogenic cholestasis in young and adults: ATP8B1, ABCB11, ABCB4, and TJP2 gene variants analysis by high-throughput sequencing.Semantic proximity Read ↗

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