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Article

Deciphering novel genotypic biomarkers and functional alterations in double strand break repair pathways for Parkinson's disease.

Scientific reports - 11 Mar 2026

Chen Chao-Hsuan, Tsai Chia-Wen, Chang Wen-Shin, Lu Ming-Kuei, Cho Der-Yang, Bau Da-Tian

Abstract excerpt

Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by dopaminergic neuronal loss and α-synuclein aggregation, with evidence implicating impaired DNA double-strand break (DSB) repair in disease pathogenesis. This study aimed to systematically evaluate the association between genetic polymorphisms in DSB repair pathway genes, including XRCC4, XRCC5, XRCC6, XRCC7, LIG4, MRE11, RAD50,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41813791
DOI: 10.1038/s41598-026-43533-5
PMCID: PMC13102983

Genes

XRCC6
NBN
RAD50
XRCC4
LIG4
MRE11
XRCC5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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