Article

Longitudinal Assessment of DNA Repair Signature Trajectory in Prodromal versus Established Parkinson’s Disease

2025-03-20

Abstract excerpt

Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by motor and non-motor symptoms. DNA repair dysfunction and integrated stress response (ISR) dysregulation have been suggested to be relevant in PD pathophysiology, but their role during the prodromal phase, before motor symptoms manifest, remains unclear. In this study, we analyzed longitudinal blood transcriptomic data from the Pa...

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Literature Corpus work: aa4733eb-b72d-5e23-ac25-82654c705961
DOI: 10.1101/2025.03.19.25324249

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