Article
Factor VIII restores bone parameters and modulates muscle proteo-metabolome in Factor VIII knockout male mice.
Bone research - 11 Mar 2026
Babuty Antoine, Muñoz-Garcia Javier, Christophe Olivier D, Fradet Laurie, Taupin Manon, Cochonneau Denis, Ollivier Emilie, Driessler Frank, Lange Claudia, Boychenko Oleksandr, Heymann Marie-Françoise, Heymann Dominique
Abstract excerpt
In addition to its role in hemostasis, Factor VIII (FVIII) has recently been shown to potentially impact angiogenesis, inflammation, osteopenia, and sarcopenia. This was explored here by studying the musculoskeletal development of FVIII knockout (FVIII-/-) male mice. These animals developed an osteoporotic phenotype with significant bone microarchitectural alteration, reduced vascularization, and a lower...
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