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Article

Platelet dysfunction and a high bone mass phenotype in a murine model of platelet-type von Willebrand disease.

The American journal of pathology - 1 Feb 2008

Suva Larry J, Hartman Eric, Dilley Joshua D, Russell Susan, Akel Nisreen S, Skinner Robert A, Hogue William R, Budde Ulrich, Varughese Kottayil I, Kanaji Taisuke, Ware Jerry

Abstract excerpt

The platelet glycoprotein Ib-IX receptor binds surface-bound von Willebrand factor and supports platelet adhesion to damaged vascular surfaces. A limited number of mutations within the glycoprotein Ib-IX complex have been described that permit a structurally altered receptor to interact with soluble von Willebrand factor, and this is the molecular basis of platelet-type von Willebrand disease. We have developed...

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Source

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Identifiers

PMID: 18187573
DOI: 10.2353/ajpath.2008.070417
PMCID: PMC2312362

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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