Article
A covR promoter mutation enhances Group B Streptococcus virulence by upregulating pgaC to reinforce capsular surface anchoring.
International journal of biological macromolecules - 1 Apr 2026
Ma Weiyi, Li Fengyang, Zhang Yong-An, Zeng Hui
Abstract excerpt
Group B Streptococcus (GBS) is a major zoonotic pathogen responsible for neonatal sepsis and cerebrospinal meningitis. A single adenine (T) insertion in the covR promoter, identified in a clinical isolate, has been shown to enhance pathogenicity. However, the mechanistic basis remains unclear. In this study, we demonstrated that this insertion downregulates covR expression and enhances hemolysin production....
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