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Article

Truncating Variants in TTN are Associated With Primary Atrial Myopathy.

Journal of the American Heart Association - 17 Mar 2026

de Castro Daniel, Fatkin Diane, Rodriguez-Rubio Enrique, Haddad Francois, Hernández-Terciado Fernando, Purohit Anisha, Bagherzadeh Shadi P, Nair Priyanka, Rad Aria, Krysov Vikki A, Parikh Victoria N, García-Pavia Pablo, Lakdawala Neal K

Abstract excerpt

BACKGROUND: Truncating TTN variants (TTNtv) are the main genetic cause of dilated cardiomyopathy (DCM) and are independently associated with atrial fibrillation (AF). In DCM, AF usually arises from left atrial (LA) remodeling attributable to left ventricular systolic dysfunction. Whether TTNtv are linked to primary LA dysfunction independent of left ventricular systolic dysfunction remains unclear. METHODS: This...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41804889
DOI: 10.1161/JAHA.125.047740
PMCID: PMC13055807

Genes

TTN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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