Article

Prevalence and clinical importance of titin truncating variants in adults without known congestive heart failure

2019-08-20

Abstract excerpt

<h4>Background</h4> Cross-sectional studies of various forms of dilated cardiomyopathy have noted a truncating mutation in the gene encoding titin (‘TTNtv’) in 7-30% of patients, but the clinical importance of identifying a TTNtv in an asymptomatic adult is largely unknown. In contrast to cross-sectional studies, prospective cohort studies allow for unbiased estimates of the disease risks associated with a genotyp...

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Literature Corpus work: 6a4e3c67-7923-585a-a85d-4278fa43b576
DOI: 10.1101/19005058

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