Clinical Phenotypes and Prognosis of Dilated Cardiomyopathy Caused by Truncating Variants in the TTN Gene.

doi:10.1161/CIRCHEARTFAILURE.119.006832

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Article

Clinical Phenotypes and Prognosis of Dilated Cardiomyopathy Caused by Truncating Variants in the TTN Gene.

Circulation. Heart failure - 1 Oct 2020

Akhtar Mohammed Majid, Lorenzini Massimiliano, Cicerchia Marcos, Ochoa Juan Pablo, Hey Thomas Morris, Sabater Molina Maria, Restrepo-Cordoba Maria Alejandra, Dal Ferro Matteo, Stolfo Davide, Johnson Renee, Larrañaga-Moreira José M, Robles-Mezcua Ainhoa, Rodriguez-Palomares Jose F, Casas Guillem, Peña-Peña Maria Luisa, Lopes Luis Rocha, Gallego-Delgado Maria, Franaszczyk Maria, Laucey Gemma, Rangel-Sousa Diego, Basurte Mayte, Palomino-Doza Julian, Villacorta Eduardo, Bilinska Zofia, Limeres Freire Javier, Garcia Pinilla José M, Barriales-Villa Roberto, Fatkin Diane, Sinagra Gianfranco, Garcia-Pavia Pablo, Gimeno Juan R, Mogensen Jens, Monserrat Lorenzo, Elliott Perry M

Abstract excerpt

BACKGROUND: Truncating variants in the TTN gene (TTNtv) are the commonest cause of heritable dilated cardiomyopathy. This study aimed to study the phenotypes and outcomes of TTNtv carriers. METHODS: Five hundred thirty-seven individuals (61% men; 317 probands) with TTNtv were recruited in 14 centers (372 [69%] with baseline left ventricular systolic dysfunction [LVSD]). Baseline and longitudinal clinical data...

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PMID: 32964742
DOI: 10.1161/CIRCHEARTFAILURE.119.006832

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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