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Article

Early-onset atrial fibrillation patients show reduced left ventricular ejection fraction and increased atrial fibrosis.

Scientific reports - 22 Jun 2020

Andreasen Laura, Bertelsen Litten, Ghouse Jonas, Lundegaard Pia R, Ahlberg Gustav, Refsgaard Lena, Rasmussen Torsten B, Eiskjær Hans, Haunsø Stig, Vejlstrup Niels, Svendsen Jesper H, Olesen Morten S

Abstract excerpt

Atrial fibrillation (AF) has traditionally been considered an electrical heart disease. However, genetic studies have revealed that the structural architecture of the heart also play a significant role. We evaluated the functional and structural consequences of harboring a titin-truncating variant (TTNtv) in AF patients, using cardiac magnetic resonance (CMR). Seventeen early-onset AF cases carrying a TTNtv, were...

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Identifiers

PMID: 32572052
DOI: 10.1038/s41598-020-66671-w
PMCID: PMC7308347

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