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Article

SMARCA4-deficient carcinoma of the head and neck region: report of 8 new sinonasal and non-sinonasal cases and literature review.

Virchows Archiv : an international journal of pathology - 1 May 2026

Farkas Mihaela, Agaimy Abbas, Švajdler Marián, Hauer Lukáš, Martínek Petr, Vaněček Tomáš, Pivovarčíková Kristýna, Prchlíková Barbora, Simpson Roderick H W, Gočárová Klaudia, Vereš Peter, Slavík Petr, Behenská Kristýna, Marjanovic Ksenija, Michal Michal, Skálová Alena, Bradová Martina

Abstract excerpt

Neoplasms with inactivating mutations in SWI/SNF chromatin remodeling complex subunits gained attention in the head and neck (H&N) region due to their poor clinical outcomes. The sinonasal tract is a recognized "hot-spot" for SMARCA4-deficient cancers, including SMARCA4-deficient sinonasal carcinomas, and most sinonasal teratocarcinosarcomas. To date, only two H&N SMARCA4-deficient carcinomas have been reported...

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Identifiers

PMID: 41803273
DOI: 10.1007/s00428-026-04459-5
PMCID: PMC13176017

Genes

SMARCA4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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SMARCA4-deficient carcinoma of the head and neck region: report of 8 new sinonasal and non-sinonasal cases and literature review.PMID 41803273Read ↗

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