Article
Targeted next-generation sequencing reveals activating CTNNB1 mutations in SMARCA4/BRG1-deficient sinonasal carcinomas: a report of two new cases and a brief review of the literature with an emphasis on histogenesis.
Virchows Archiv : an international journal of pathology - 1 Feb 2023
Zhao Ming, Ma Tianshi, He Xianglei, Ge Minghua
Abstract excerpt
SMARCA4/BRG1 is a catalytic subunit of the SWItch/sucrose non-fermentable (SWI/SNF) complex and its inactivation is known to drive a variety of cancers across different organs. SMARCA4/BRG1-deficient carcinoma is a relatively new entity in the sinonasal region, and a comprehensive molecular investigation of the underlying genetic abnormalities is largely lacking. In this study, we report two new cases of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.