Article
Comprehensive Molecular Profiling of Sinonasal Teratocarcinosarcoma Highlights Recurrent SMARCA4 Inactivation and CTNNB1 Mutations.
The American journal of surgical pathology - 1 Feb 2023
Rooper Lisa M, Agaimy Abbas, Gagan Jeffrey, Simpson Roderick H W, Thompson Lester D R, Trzcinska Anna M, Ud Din Nasir, Bishop Justin A
Abstract excerpt
Sinonasal teratocarcinosarcoma (TCS) is a rare tumor defined by intermixed neuroepithelial, mesenchymal, and epithelial elements. While its etiology was historically ambiguous, we recently reported frequent SMARCA4 loss by immunohistochemistry, suggesting that TCS might be related to SMARCA4-deficient sinonasal carcinomas. However, other molecular alterations including CTNNB1 mutation have been reported in TCS,...
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