Association of IL4 and IL17A genetic polymorphisms with COVID-19 severity in a southern Brazilian population.

doi:10.1016/j.humimm.2026.111709

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Article

Association of IL4 and IL17A genetic polymorphisms with COVID-19 severity in a southern Brazilian population.

Human immunology - 1 May 2026

Drehmer Manuela Nunes, Castro Gabriel Vaisam, Lazzari Daniele Delacanal, Pinto Guimarães Luciano Santos, Sortica Vinicius de Albuquerque, Possuelo Lia Gonçalves, Moura Valim Andreia Rosane de, Costa Giulia Souza da, Gambin Izza, Genro Julia Pasqualini, Netto Muniz Yara Costa, Lindenau Juliana Dal-Ri

Abstract excerpt

COVID-19 has demonstrated marked differences in clinical manifestations and outcomes, with severe cases presenting excessive inflammatory responses known as cytokine storms. Polymorphisms in cytokine genes, such as interleukin-4 (IL4) and interleukin-17A (IL17A), may influence immune responses an...

Topics

Humans
Interleukin-17
Brazil
Female
COVID-19
Male
SARS-CoV-2
Interleukin-4
Middle Aged
Severity of Illness Index
Adult
Genetic Predisposition to Disease
Polymorphism, Single Nucleotide

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genotype

Aged

Pandemics

Gene Frequency

Source

Open in PubMed

Identifiers

PMID: 41797095
DOI: 10.1016/j.humimm.2026.111709

Genes

IL4
IL17A

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-41797095-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.