Association between IL-17A (rs2275913), IL-4 (rs2070874), NLRP3 (rs10754558) polymorphisms and COVID-19 in a cohort of professionals who worked in the first pandemic wave.

doi:10.1016/j.humimm.2026.111712

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Article

Association between IL-17A (rs2275913), IL-4 (rs2070874), NLRP3 (rs10754558) polymorphisms and COVID-19 in a cohort of professionals who worked in the first pandemic wave.

Human immunology - 1 May 2026

Silva Vieira Marcelo Cleyton da, Marcelino Beatriz Dos Reis, Abrahão Silva Marcos Jessé, Sardinha Daniele Melo, Sousa Bispo Sebastião Kauã de, Gondim Costa Lima Luana Nepomuceno, Batista Lima Karla Valéria

Abstract excerpt

INTRODUCTION: Host genetic polymorphisms in inflammatory mediators may influence COVID-19 clinical outcomes. This study investigated associations between IL-17A (rs2275913), IL-4 (rs2070874), and NLRP3 (rs10754558) polymorphisms and COVID-19 presentation in professionals exposed during the first...

Topics

Humans
NLR Family, Pyrin Domain-Containing 3 Protein
Interleukin-17
Female
Interleukin-4
Male

Source

Open in PubMed

Identifiers

PMID: 41812550
DOI: 10.1016/j.humimm.2026.111712

Genes

NLRP3
SI

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-41812550-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Adult

Middle Aged

Polymorphism, Single Nucleotide

COVID-19

SARS-CoV-2

Brazil

Genetic Predisposition to Disease

Genotype

Pandemics

Alleles

Gene Frequency