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Cellular and behavioral characterization of <i>Pcdh19</i> mutant mice: subtle molecular changes, increased exploratory behavior and an impact of social environment

2020-08-28

Abstract excerpt

<h4>ABSTRACT</h4> Mutations in the X-linked cell adhesion protein PCDH19 lead to seizures, cognitive impairment and other behavioral comorbidities when present in a mosaic pattern. Neither the molecular mechanisms underpinning this disorder, nor the function of PCDH19 itself are well understood. By combining RNA in situ hybridization with immunohistochemistry and analyzing single cell RNAseq datasets, we provide...

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Literature Corpus work
e4d4009f-a7df-587d-9620-ebf30872632a
DOI
10.1101/2020.08.27.271239
Open publication

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Cellular and behavioral characterization of <i>Pcdh19</i> mutant mice: subtle molecular changes, increased exploratory behavior and an impact of social environmentDOI 10.1101/2020.08.27.271239
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