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Article

Pharmacogenetics of RAS-affecting AGT and ACE variants and the efficacy of Valsartan/HCTZ therapy.

Scientific reports - 7 Mar 2026

Baig Alija, Shah Syed Muhammad Mukarram, Alfaiz Abdulrahman Saad, Alammar Muath A, Alotaibi Mohammad Dhuwayhi Ghazi, Rauf Abdur, Begum Aiman, Hassan Zia Ul, Ainy Noorulain, Babaresh Wahby Mohammed, Zakiullah

Abstract excerpt

Considerable inter-individual variability has been observed in the blood pressure response to valsartan/hydrochlorothiazide (Valsartan/HCTZ), and genetic differences within the renin-angiotensin system may contribute to this heterogeneity. This prospective cohort study included 354 hypertensive patients treated with Valsartan/HCTZ (80/12.5 mg or 160/12.5 mg). Baseline and 4-week BP measurements were recorded...

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Share to Angiotensinogen
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Peptidyl-Dipeptidase A

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Source

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Identifiers

PMID: 41794841
DOI: 10.1038/s41598-026-42902-4
PMCID: PMC13087309

Genes

ACE
AGT
DBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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