Article
Association of ACE I/D polymorphism with blood pressure response to valsartan-hydrochlorothiazide combination therapy in hypertensive patients from Khyber Pakhtunkhwa, Pakistan.
Pharmacogenomics - 1 Jul 2026
Ullah Aftab, Rahim Abdur, Jan Asif, Khan Muhammad, Iqbal Junaid, Dagnaw Mequanente
Abstract excerpt
BACKGROUND: Interindividual variability in antihypertensive response may be partly explained by genetic variation. The angiotensin-converting enzyme insertion/deletion polymorphism (ACE I/D; rs1799752) has been associated with variable response to renin-angiotensin-aldosterone system-targeting therapies, but evidence for valsartan-hydrochlorothiazide (Val-HCTZ) combination therapy remains limited, particularly in...
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- Female
- Humans
- Male
- Middle Aged