Article
Interaction of ACE and CYP11B2 genes on blood pressure response to hydrochlorothiazide in Han Chinese hypertensive patients.
Clinical and experimental hypertension (New York, N.Y. : 1993) - 1 Jan 2011
Li Yun, Zhou Yong, Yang Peng, Niu Jian Qing, Wu Ying, Zhao Dan Dan, Wu Shou Ling
Abstract excerpt
To valuate whether angiotensin converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism and aldosterone synthase (CYP11B2) gene -344T/C polymorphism are associated with individual response to hydrochlorothiazide (HCTZ) in the Han Chinese population with essential hypertension. We enrolled 829 mild/moderate hypertensive patients and 12.5 mg of HCTZ was given daily. After 6 weeks, the results showed that...
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