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[Association of polymorphisms in ACE and CYP11B2 genes with antihypertensive effects of hydrochlorothiazide].

Zhonghua xin xue guan bing za zhi - 1 Jul 2005

Wu Shou-ling, Li Yun, Liu Ke-jian, Hou Guo-sheng, Wang Jian-jun, Wu Yun-Tao, Song Shao-min

Abstract excerpt

OBJECTIVE: To determine whether the blood pressure (BP) response to hydrochlorothiazide (HCTZ) was associated with the angiotensin converting-enzyme (ACE) I/D and aldosterone synthase (CYP11B2)-344T/C polymorphisms. METHODS: The BP response to HCTZ 12.5 mg once daily for 6 weeks was assessed in 829 subjects with mild or moderate essential hypertension, and compared across the ACE and CYP11B2 genotypes. RESULTS:...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 16080804

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ACE

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