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Article

Distinct molecular subtypes of papillary thyroid carcinoma and gene signature with diagnostic capability.

Oncogene - 1 Nov 2022

Hong Shubin, Xie Yubin, Cheng Zhen, Li Jie, He Weiman, Guo Zhuming, Zhang Quan, Peng Sui, He Minghui, Yu Shuang, Xu Lixia, Liu Rengyun, Xu Tianyi, Zhang Yunjian, Li Yanbing, Wang Jiguang, Lv Weiming, Yu Jun, Xiao Haipeng

Abstract excerpt

Papillary thyroid carcinoma (PTC) is heterogeneous and its molecular characteristics remain elusive. We integrated transcriptomic sequencing, genomic analysis and clinicopathologic information from 582 tissue samples of 216 PTC and 75 benign thyroid nodule (BTN) patients. We discovered four subtypes of PTC including Immune-enriched Subtype, BRAF-enriched Subtype, Stromal Subtype and CNV-enriched Subtype....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 36253446
DOI: 10.1038/s41388-022-02499-0
PMCID: PMC9674518

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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